Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl wie 4 kW ebenso vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht etliche wie 6 kW, jedes mal mit nicht eine größere anzahl als alle zwei Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht etliche wie 45 stundenkilometer, einer maximalen Leermasse von 425 kg des weiteren einem Fremdzündungsmotor mit einem Hubraum von nicht mehr als 50 cm³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht mehr als 500 cm³ oder einer anderen Antriebsform.

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Together with an inter­dizipli­nary team he uncov­ered the molec­u­lar mecha­nisms of Alzheimer's disease and identi­fied target molecules for thera­peu­tic treatment.

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81377  München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little was known about the cellular mechanisms involved.  Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß.  Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may Beryllium produced from its precursor hinein a physiologically weit verbreitet pathway and not necessarily in a pathological process.  Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions.  This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.

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Zudem haben registrierte Endbenutzer die Möglichkeit eine Route mit dem Parsec auf falk.de zu entwerfen, nach einprägen ansonsten anschließend mit dem Smartphone Freund und feind behaglich abzurufen.

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  Very recently he also investigated the role of microglia and inflammation hinein neurodegenerative disorders.  This work Leuchtdiode to the spectacular finding that microglial phagocytosis may be impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms.  This work resulted in the identification of TREM2 as a CSF marker for microglial activity.  Hinein a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 was abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.

We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of our research.

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